Enantiomers of HA-966 (3-amino-1-hydroxypyrrolid-2-one) exhibit distinct central nervous system effects: (+)-HA-966 is a selective glycine/N-methyl-D-aspartate receptor antagonist, but (-)-HA-966 is a potent gamma-butyrolactone-like sedative.

Singh, L.; Donald, A. E.; Foster, A. C.; Hutson, P. H.; Iversen, L. L.; Iversen, S. D.; Kemp, J. A.; Leeson, P. D.; Marshall, G. R.; Oles, R. J.

期刊名称Proceedings of the National Academy of Sciences
作者Singh, L.; Donald, A. E.; Foster, A. C.; Hutson, P. H.; Iversen, L. L.; Iversen, S. D.; Kemp, J. A.; Leeson, P. D.; Marshall, G. R.; Oles, R. J.
卷第87卷
期第1期
印刷ISSN0027-8424
电子ISSN1091-6490
文件大小974.35KB
发表时间1990-01-01
DOI10.1073/pnas.87.1.347
页码347-351

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