[ASCRIT] Antisense chemoradioimmunotherapy consisting of anti-POEM (Arg-Gly-Asp) scFv linked onto high-energy radioisotopes, vinorelbine-tartrate and 21-nucleotide double-stranded siRNA targeted to DNMT1 induce apoptosis in metastatic breast cancer (MBC) characterized by hypermethylated p53, p16, RASSF1A, RAR-b2, BRCA2, H1C1, ESRI1, CDH1, Trbeta1, GSTP1, CCND2 and overexpression of bcl-2, cdc25c, Raf-1 and α8β1 integrin
J Giannios, P Lambrinos, E Maragudakis, N Alexandropoulos
- 作者J Giannios, P Lambrinos, E Maragudakis, N Alexandropoulos
- 卷第7卷
- 文件大小617.84KB
- 发表时间2005-05
- DOI10.1186/bcr1247