Design of a potent, soluble glucokinase activator with increased pharmacokinetic half-life
- 作者Kurt G. Pike; Joanne V. Allen; Peter W.R. Caulkett; David S. Clarke; Craig S. Donald; Mark L. Fenwick; Keith M. Johnson; Craig Johnstone; Darren McKerrecher; John W. Rayner; Rolf P. Walker; Ingrid Wilson
- 卷第21卷
- 期第11期
- 印刷ISSN0960-894X
- 文件大小695.82KB
- 发表时间2011
- DOI10.1016/j.bmcl.2011.03.093
- 页码3467-3470
Synthesis and in Vitro Evaluation of Sulfonamide Isatin Michael Acceptors as Small Molecule Inhibitors of Caspase-6Chu, Wenhua; Rothfuss, Justin; Chu, Yunxiang; Zhou, Dong; Mach, Robert H. · Journal of Medicinal Chemistry · 2009
Comparison of radiolabeled isatin analogs for imaging apoptosis with positron emission tomographyDelphine L. Chen; Dong Zhou; Wenhua Chu; Phillip E. Herrbrich; Lynne A. Jones; Justin M. Rothfuss; Jacquelyn T. Engle; Marco Geraci; Michael J. Welch; Robert H. Mach · 2009
Radiolabeled isatin binding to caspase-3 activation induced by anti-Fas antibodyDelphine L. Chen; Dong Zhou; Wenhua Chu; Phillip Herrbrich; Jacquelyn T. Engle; Elizabeth Griffin; Lynne A. Jones; Justin M. Rothfuss; Marco Geraci; Richard S. Hotchkiss; Robert H. Mach · 2012
Isatin Sulfonamide Analogs Containing a Michael Addition Acceptor: A New Class of Caspase 3/7 InhibitorsChu, Wenhua; Rothfuss, Justin; d'Avignon, André; Zeng, Chenbo; Zhou, Dong; Hotchkiss, Richard S.; Mach, Robert H. · Journal of Medicinal Chemistry · 2007
Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding siteXu, Jinbin; Zeng, Chenbo; Chu, Wenhua; Pan, Fenghui; Rothfuss, Justin M.; Zhang, Fanjie; Tu, Zhude; Zhou, Dong; Zeng, Dexing; Vangveravong, Suwanna; Johnston, Fabian; Spitzer, Dirk; Chang, Katherine C.; Hotchkiss, Richard S.; Hawkins, William G.; Wheeler, Kenneth T.; Mach, Robert H. · Nature Communications · 2011
Synthesis, radiolabeling, and in vivo evaluation of an 18F-labeled isatin analog for imaging caspase-3 activation in apoptosisDong Zhou; Wenhua Chu; Justin Rothfuss; Chenbo Zeng; Jinbin Xu; Lynne Jones; Michael J. Welch; Robert H. Mach · 2006
[18F]- and [11C]-Labeled N-benzyl-isatin sulfonamide analogues as PET tracers for Apoptosis: synthesis, radiolabeling mechanism, and in vivo imaging study of apoptosis in Fas-treated mice using [11C]WC-98Zhou, Dong; Chu, Wenhua; Chen, Delphine L.; Wang, Qi; Reichert, David E.; Rothfuss, Justin; D'Avignon, Andre; Welch, Michael J.; Mach, Robert H. · Organic & Biomolecular Chemistry · 2009