Introduction When culturing bacteria in artificial microhabitats, such as in microfluidic devices, microchambers and microreactors, the ecological and microbiological aspects must be considered. In such devices and experiments cells often live in structured environments that from an ecological viewpoint could be considered “patchy” (i.e. with strong spatial heterogeneities and variations in suitability for the cells).1 In such artificial habitats, the formation of a metapopulation, a set of interacting subpopulations, is observed along with a complex population dynamics.2 The ecological aspects are also manifested in the fact that cells compete for resources,3 which sometimes results in unexpected spatial distribution and growth of cells.4 In such biological scenarios, cell-cell communication is important.5 The complexity of the evolved communication mechanisms among prokaryotes can be distinguished by the various chemical signals used by the different bacterial species. Beside the known quorum sensing signaling molecules (homoserine lactones and oligopeptides6,7), bacteria use toxins (antibiotics, bacteriocins8), antimicrobial peptides,9 amino acids,10 exopolysaccharides,11 or metabolic waste products (indole11) as signaling molecules. These chemical signals have distinguishable targets and functions (intra-, or interspecies communication, inter-kingdom signaling), and they have a key role in the communication of bacterial populations in natural habitats. Motile bacteria have the great advantage of being able to explore the heterogeneous environment. By a mechanism called chemotaxis bacteria are able to sense concentration changes of certain chemicals, and swim towards increasing or decreasing concentrations of chemoattractants or chemorepellent molecules, respectively.13,14 It has been shown that signaling and chemotaxis may be coupled, and signaling molecules may act as chemoeffectors.5 Although traditional microbiology techniques enable us to study the interact

• 期刊名称Chemical and Biochemical Engineering Quarterly Journal
• 作者Nagy, K.; Sipos, O.; Gombai, É.; Kerényi, Á.; Valkai, S.; Ormos, P.; Galajda, P.
• 卷第28卷
• 期第2期
• 印刷ISSN0352-9568
• 电子ISSN1846-5153
• 文件大小1376.28KB
• 发表时间2014
• DOI10.15255/cabeq.2013.1934
• 页码225-231