Discovery and Optimization of Quinazolinone-pyrrolopyrrolones as Potent and Orally Bioavailable pan-Pim Kinase Inhibitors

Pettus, Liping H.; Andrews, Kristin L.; Booker, Shon K.; Chen, Jie; Cee, Victor J.; Chavez Jr., Frank; Chen, Yuping; Eastwood, Heather; Guerrero, Nadia; Herberich, Bradley James; Hickman, Dean; Lanman, Brian A; Laszlo III, Jimmy; Lee, Matthew Randolph; Lipford, J. Russell; Mattson, Bethany; Mohr, Christopher; Nguyen, Yen; Norman, Mark H; Powers, David; Reed, Anthony B.; Rex, Karen; Sastri, Christine; Tamayo, Nuria A.; Wang, Paul; Winston, Jeffrey T.; Wu, Bin; Wu, Tian; Wurz, Ryan P.; Xu, Yang; Zhou, Yihong; Tasker, Andrew S; Wang, Hui-Ling

期刊名称Journal of Medicinal Chemistry
作者Pettus, Liping H.; Andrews, Kristin L.; Booker, Shon K.; Chen, Jie; Cee, Victor J.; Chavez Jr., Frank; Chen, Yuping; Eastwood, Heather; Guerrero, Nadia; Herberich, Bradley James; Hickman, Dean; Lanman, Brian A; Laszlo III, Jimmy; Lee, Matthew Randolph; Lipford, J. Russell; Mattson, Bethany; Mohr, Christopher; Nguyen, Yen; Norman, Mark H; Powers, David; Reed, Anthony B.; Rex, Karen; Sastri, Christine; Tamayo, Nuria A.; Wang, Paul; Winston, Jeffrey T.; Wu, Bin; Wu, Tian; Wurz, Ryan P.; Xu, Yang; Zhou, Yihong; Tasker, Andrew S; Wang, Hui-Ling
印刷ISSN0022-2623
电子ISSN1520-4804
文件大小1384.14KB
发表时间2016-06-10
DOI10.1021/acs.jmedchem.6b00610

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Discovery and Optimization of Quinazolinone-pyrrolopyrrolones as Potent and Orally Bioavailable pan-Pim Kinase Inhibitors