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Identification of (R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, Suitable for Phase I Clinical Trials for B-Cell Lymphomas

Identification of (R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, Suitable for Phase I Clinical Trials for B-Cell Lymphomas

Vaswani, Rishi G; Gehling, Victor S; Dakin, Les A.; Cook, Andrew; Nasveschuk, Christopher G.; Duplessis, Martin; Iyer, Priyadarshini; Balasubramanian, Srividya; Zhao, Feng; Good, Andrew C; Campbell, Robert; Lee, Christina; Cantone, Nico; Cummings, Richard T.; Normant, Emmanuel; Bellon, Steven F.; Albrecht, Brian K.; Harmange, Jean-Christophe P.; Trojer, Patrick; Audia, James E.; Zhang, Ying; Justin, Neil; Chen, Shuyang; Wilson, Jon; Gamblin, Steve
  • 期刊名称Journal of Medicinal Chemistry
  • 作者Vaswani, Rishi G; Gehling, Victor S; Dakin, Les A.; Cook, Andrew; Nasveschuk, Christopher G.; Duplessis, Martin; Iyer, Priyadarshini; Balasubramanian, Srividya; Zhao, Feng; Good, Andrew C; Campbell, Robert; Lee, Christina; Cantone, Nico; Cummings, Richard T.; Normant, Emmanuel; Bellon, Steven F.; Albrecht, Brian K.; Harmange, Jean-Christophe P.; Trojer, Patrick; Audia, James E.; Zhang, Ying; Justin, Neil; Chen, Shuyang; Wilson, Jon; Gamblin, Steve
  • 印刷ISSN0022-2623
  • 电子ISSN1520-4804
  • 文件大小1200.41KB
  • 发表时间2016-10-14
  • DOI10.1021/acs.jmedchem.6b01315
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