Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors

Arce Vargas, Frederick; Furness, Andrew J.S.; Solomon, Isabelle; Joshi, Kroopa; Mekkaoui, Leila; Lesko, Marta H.; Miranda Rota, Enrique; Dahan, Rony; Georgiou, Andrew; Sledzinska, Anna; Ben Aissa, Assma; Franz, Dafne; Werner Sunderland, Mariana; Wong, Yien Ning Sophia; Henry, Jake Y.; O’Brien, Tim; Nicol, David; Challacombe, Ben; Beers, Stephen A.; Turajlic, Samra; Gore, Martin; Larkin, James; Swanton, Charles; Chester, Kerry A.; Pule, Martin; Ravetch, Jeffrey V.; Marafioti, Teresa; Peggs, Karl S.; Quezada, Sergio A.; Spain, Lavinia; Wotherspoon, Andrew; Francis, Nicholas; Smith, Myles; Strauss, Dirk; Hayes, Andrew; Soultati, Aspasia; Stares, Mark; Spain, Lavinia; Lynch, Joanna; Fotiadis, Nicos; Fernando, Archana; Hazell, Steve; Chandra, Ashish; Pickering, Lisa; Rudman, Sarah; Chowdhury, Simon; Swanton, Charles; Jamal-Hanjani, Mariam; Veeriah, Selvaraju; Shafi, Seema; Czyzewska-Khan, Justyna; Johnson, Diana; Laycock, Joanne; Bosshard-Carter, Leticia; Goh, Gerald; Rosenthal, Rachel; Gorman, Pat; Murugaesu, Nirupa; Hynds, Robert E.; Wilson, Gareth; Birkbak, Nicolai J.; Watkins, Thomas B.K.; McGranahan, Nicholas; Horswell, Stuart; Mitter, Richard; Escudero, Mickael; Stewart, Aengus; Van Loo, Peter; Rowan, Andrew; Xu, Hang; Turajlic, Samra; Hiley, Crispin; Abbosh, Christopher; Goldman, Jacki; Stone, Richard Kevin; Denner, Tamara; Matthews, Nik; Elgar, Greg; Ward, Sophia; Biggs, Jennifer; Costa, Marta; Begum, Sharmin; Phillimore, Ben; Chambers, Tim; Nye, Emma; Graca, Sofia; Al Bakir, Maise; Hartley, John A.; Lowe, Helen L.; Herrero, Javier; Lawrence, David; Hayward, Martin; Panagiotopoulos, Nikolaos; Kolvekar, Shyam; Falzon, Mary; Borg, Elaine; Simeon, Celia; Hector, Gemma; Smith, Amy; Aranda, Marie; Novelli, Marco; Oukrif, Dahmane; Janes, Sam M.; Thakrar, Ricky; Forster, Martin; Ahmad, Tanya; Lee, Siow Ming; Papadatos-Pastos, Dionysis; Carnell, Dawn; Mendes, Ruheena; George, Jeremy; Navani, Neal; Ahmed, Asia; Taylor, Magali; Choudhary, Junaid; Summers, Yvonne; Califano

期刊名称Immunity
作者Arce Vargas, Frederick; Furness, Andrew J.S.; Solomon, Isabelle; Joshi, Kroopa; Mekkaoui, Leila; Lesko, Marta H.; Miranda Rota, Enrique; Dahan, Rony; Georgiou, Andrew; Sledzinska, Anna; Ben Aissa, Assma; Franz, Dafne; Werner Sunderland, Mariana; Wong, Yien Ning Sophia; Henry, Jake Y.; O’Brien, Tim; Nicol, David; Challacombe, Ben; Beers, Stephen A.; Turajlic, Samra; Gore, Martin; Larkin, James; Swanton, Charles; Chester, Kerry A.; Pule, Martin; Ravetch, Jeffrey V.; Marafioti, Teresa; Peggs, Karl S.; Quezada, Sergio A.; Spain, Lavinia; Wotherspoon, Andrew; Francis, Nicholas; Smith, Myles; Strauss, Dirk; Hayes, Andrew; Soultati, Aspasia; Stares, Mark; Spain, Lavinia; Lynch, Joanna; Fotiadis, Nicos; Fernando, Archana; Hazell, Steve; Chandra, Ashish; Pickering, Lisa; Rudman, Sarah; Chowdhury, Simon; Swanton, Charles; Jamal-Hanjani, Mariam; Veeriah, Selvaraju; Shafi, Seema; Czyzewska-Khan, Justyna; Johnson, Diana; Laycock, Joanne; Bosshard-Carter, Leticia; Goh, Gerald; Rosenthal, Rachel; Gorman, Pat; Murugaesu, Nirupa; Hynds, Robert E.; Wilson, Gareth; Birkbak, Nicolai J.; Watkins, Thomas B.K.; McGranahan, Nicholas; Horswell, Stuart; Mitter, Richard; Escudero, Mickael; Stewart, Aengus; Van Loo, Peter; Rowan, Andrew; Xu, Hang; Turajlic, Samra; Hiley, Crispin; Abbosh, Christopher; Goldman, Jacki; Stone, Richard Kevin; Denner, Tamara; Matthews, Nik; Elgar, Greg; Ward, Sophia; Biggs, Jennifer; Costa, Marta; Begum, Sharmin; Phillimore, Ben; Chambers, Tim; Nye, Emma; Graca, Sofia; Al Bakir, Maise; Hartley, John A.; Lowe, Helen L.; Herrero, Javier; Lawrence, David; Hayward, Martin; Panagiotopoulos, Nikolaos; Kolvekar, Shyam; Falzon, Mary; Borg, Elaine; Simeon, Celia; Hector, Gemma; Smith, Amy; Aranda, Marie; Novelli, Marco; Oukrif, Dahmane; Janes, Sam M.; Thakrar, Ricky; Forster, Martin; Ahmad, Tanya; Lee, Siow Ming; Papadatos-Pastos, Dionysis; Carnell, Dawn; Mendes, Ruheena; George, Jeremy; Navani, Neal; Ahmed, Asia; Taylor, Magali; Choudhary, Junaid; Summers, Yvonne; Califano
卷第46卷
期第4期
印刷ISSN1074-7613
文件大小4884.40KB
发表时间2017-04
DOI10.1016/j.immuni.2017.03.013
页码577-586

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Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors