Small molecule neuropilin-1 antagonists combine anti-angiogenic and anti-tumour activity with immune modulation through reduction of transforming growth factor beta (TGFβ) production in regulatory T-cells

Powell, Jonathan; Mota, Filipa; Steadman, David; Soudy, Christelle; Miyauchi, Jeremy T; Crosby, Stuart; Jarvis, Ashley; Reisinge, Tifelle; Winfield, Natalie; Evans, Graham; Finniear, Aled; Yelland, Tamas; Chou, Yi-Tai; Chan, A.W. Edith; O'Leary, Andrew; Cheng, Lili; Liu, Dan; Fotinou, Ntina; Milagre, Carla; Martin, John F; Jia, Haiyan; Frankel, Paul; Djordjevic, Snezana; Tsirka, Stella E; Zachary, Ian C.; Selwood, David L

期刊名称Journal of Medicinal Chemistry
作者Powell, Jonathan; Mota, Filipa; Steadman, David; Soudy, Christelle; Miyauchi, Jeremy T; Crosby, Stuart; Jarvis, Ashley; Reisinge, Tifelle; Winfield, Natalie; Evans, Graham; Finniear, Aled; Yelland, Tamas; Chou, Yi-Tai; Chan, A.W. Edith; O'Leary, Andrew; Cheng, Lili; Liu, Dan; Fotinou, Ntina; Milagre, Carla; Martin, John F; Jia, Haiyan; Frankel, Paul; Djordjevic, Snezana; Tsirka, Stella E; Zachary, Ian C.; Selwood, David L
印刷ISSN0022-2623
电子ISSN1520-4804
文件大小1865.82KB
发表时间2018-04-12
DOI10.1021/acs.jmedchem.8b00210

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Small molecule neuropilin-1 antagonists combine anti-angiogenic and anti-tumour activity with immune modulation through reduction of transforming growth factor beta (TGFβ) production in regulatory T-cells