Discovery of (R)-8-(6-Methyl-4-oxo-1,4,5,6-tetrahydropyrrolo[3,4-b]pyrrol-2-yl)-3-(1-methylcyclopropyl)-2-((1-methylcyclopropyl)amino)quinazolin-4(3H)-one, a Potent and Selective Pim- 1/2 Kinase Inhibitor for Hematological Malignancies

Wang, Hui-Ling; Andrews, Kristin; Booker, Shon K.; Canon, Jude; Cee, Victor J.; Chavez Jr., Frank; Chen, Yuping; Eastwood, Heather; Guerrero, Nadia; Herberich, Bradley; Hickman, Dean; Lanman, Brian A; Laszlo III, Jimmy; Lee, Matthew R; Lipford, J. Russell; Mattson, Bethany; Mohr, Christopher; Nguyen, Yen; Norman, Mark H; Pettus, Liping H.; Powers, David; Reed, Anthony B.; Rex, Karen; Sastri, Christine; Tamayo, Nuria A.; Wang, Paul; Winston, Jeffrey T.; Wu, Bin; Wu, Qiong; Wu, Tian; Wurz, Ryan P.; Xu, Yang; Zhou, Yihong; Tasker, Andrew S

期刊名称Journal of Medicinal Chemistry
作者Wang, Hui-Ling; Andrews, Kristin; Booker, Shon K.; Canon, Jude; Cee, Victor J.; Chavez Jr., Frank; Chen, Yuping; Eastwood, Heather; Guerrero, Nadia; Herberich, Bradley; Hickman, Dean; Lanman, Brian A; Laszlo III, Jimmy; Lee, Matthew R; Lipford, J. Russell; Mattson, Bethany; Mohr, Christopher; Nguyen, Yen; Norman, Mark H; Pettus, Liping H.; Powers, David; Reed, Anthony B.; Rex, Karen; Sastri, Christine; Tamayo, Nuria A.; Wang, Paul; Winston, Jeffrey T.; Wu, Bin; Wu, Qiong; Wu, Tian; Wurz, Ryan P.; Xu, Yang; Zhou, Yihong; Tasker, Andrew S
印刷ISSN0022-2623
电子ISSN1520-4804
文件大小817.37KB
发表时间2019-01-09
DOI10.1021/acs.jmedchem.8b01733

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Discovery of (R)-8-(6-Methyl-4-oxo-1,4,5,6-tetrahydropyrrolo[3,4-b]pyrrol-2-yl)-3-(1-methylcyclopropyl)-2-((1-methylcyclopropyl)amino)quinazolin-4(3H)-one, a Potent and Selective Pim- 1/2 Kinase Inhibitor for Hematological Malignancies