Free-Wilson analysis of comprehensive data on phosphoinositide-3-kinase (PI3K) inhibitors reveals importance of N -methylation for PI3Kδ activity.

• 期刊名称Journal of Medicinal Chemistry
• 作者Barnes, Lydia; Blaber, Hollie; Brooks, David T. K.; Byers, Lewis; Buckley, Daniel; Byron, Zoe C; Chilvers, Richard; Cochrane, Liam; Cooney, Edward; Damian, Heather A; Francis, Luke; Fu He, Daniel; Grace, Jack M. J.; Green, Harley J; Hogarth, Edmund J. P.; Jusu, Leyla; Killalea, C. Elizabeth; King, Oliver; Lambert, Joseph; Lee, Zoe J; Lima, Nuria S; Long, Christina L; Mackinnon, May-Li; Mahdy, Shusha; Matthews-Wright, Jolyon; Millward, Makenzie J; Meehan, Matthew F; Merrett, Christopher; Morrison, Lisa; Parke, Hal R. I.; Payne, Charlotte; Payne, Lawrence; Pike, Craig; Seal, Alexander; Senior, Aaron J; Smith, Keenan M; Stanelyte, Kamile; Stillibrand, Joe; Szpara, Rachel; Taday, Freya F. H.; Threadgould, Antony M; Trainor, Rohan J; Waters, Jordan; Williams, Oliver; Wong, Carrie K. W.; Wood, Katherine; Barton, Nick; Gruszka, Anna; Henley, Zoë A; Rowedder, James E.; Cookson, Rosa E; Jones, Katherine L.; Nadin, Alan J; Smith, Ian E; Macdonald, Simon J. F.; Nortcliffe, Andrew
• 印刷ISSN0022-2623
• 电子ISSN1520-4804
• 文件大小4735.21KB
• 发表时间2019-10-24
• DOI10.1021/acs.jmedchem.9b01499