Detection and characterization of olmutinib reactive metabolites by LC‐MS/MS: Elucidation of bioactivation pathways
- 期刊名称Journal of Separation Science
- 作者Attwa, Mohamed W.; Kadi, Adnan A.; Abdelhameed, Ali S.
- 印刷ISSN1615-9306
- 电子ISSN1615-9314
- 文件大小1239.24KB
- 发表时间2019-11-18
- DOI10.1002/jssc.201900818
Investigation of the metabolic stability of olmutinib by validated LC-MS/MS: quantification in human plasmaAttwa, Mohamed W.; Kadi, Adnan A.; Darwish, Hany W.; Abdelhameed, Ali S. · RSC Advances · 2018
Reactive Intermediates and Bioactivation Pathways Characterization of Avitinib by LC-MS/MS: In vitro Metabolic InvestigationAttwa, Mohamed W.; Kadi, Adnan A.; Abdelhameed, Ali S. · Journal of Pharmaceutical and Biomedical Analysis · 2018
Characterization of reactive intermediates formation in dacomitinib metabolism and bioactivation pathways elucidation by LC-MS/MS: <i>in vitro</i> phase I metabolic investigationAttwa, Mohamed W.; Kadi, Adnan A.; Abdelhameed, Ali S. · RSC Advances · 2018
A highly efficient and sensitive LC-MS/MS method for the determination of afatinib in human plasma: application to a metabolic stability studyKadi, Adnan A.; Abdelhameed, Ali S.; Darwish, Hany W.; Attwa, Mohamed W.; Al-Shakliah, Nasser S. · Biomedical Chromatography · 2016
A simple liquid chromatography-tandem mass spectrometry method to accurately determine the novel third-generation EGFR-TKI naquotinib with its applicability to metabolic stability assessmentAlrabiah, Haitham; Kadi, Adnan A.; Attwa, Mohamed W.; Abdelhameed, Ali S. · RSC Advances · 2019
Phase I metabolic profiling and unexpected reactive metabolites in human liver microsome incubations of X-376 using LC-MS/MS: bioactivation pathway elucidation and <i>in silico</i> toxicity studies of its metabolitesAttwa, Mohamed W.; Kadi, Adnan A.; Abdelhameed, Ali S. · RSC Advances · 2020
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